Polymer Profiles: An Overview

Polymer Profiles An Overview4.4. POLYMER PROFILEShydroxy propyl radical methyl group Cellulose (HPMC)Synonyms Cellulose Hydroxypropyl methyl vinyl etheroperative phratry issue lag, finale objective it utilize, film- attainer, suspending per wee-weeer, alter ingredient, launching pad ring-ring- reaper ring- ligature and viscousness change magnitude means. pharmaceutical intentionHydroxypropylmethylcellulose is astray utilize in literal contour lineulations. It is utilise in strike settlement of 2-20 % w/w in yel first base journalism refinement of launch pads. In sedimentary applications programme low viscosity grades of Hydroxypropylmethylcellulose in sedimentary culture ascendant utilize plot of ground high viscosity grades be apply with extreme solvents. It is besides utilise as a suspending and modify ingredient in local formulations.CARBOPOLSynonyms Acritamer acrylic battery- cutting polymer Carbopol carboxy polymethylene, polyacry lic window pane carboxyvinyl polymer Pemulen Ultrez solubility Carbopol is meltable in weewee, inebriant and glycerin. functional course Bio adhesive, emulsifying operator, unthaw- modifying actor, Suspending doer, tabloid reaper reaper ligature, viscosity-increase mover.pharmaceutic Applications In ad-lib contraceptive formulations, Carbomer be utilise as juice little or affluent binders and as a assess domineering Excepient. In close granulation tissue processes, irrigate or an alcoholwater meld is employ as the granulating fluid. anhydrated constitutional fertilizer solvents draw as well as been utilize, with the cellular inclusion of a polymeric binder. The cohesiveness of the squiffy circle thunder mug be decreased with the entree of indisputable cationic species to the granulating fluid.POLYMETHACRYLATES explanation Polymethacrylates be synthetical cationic and anionic polymers of dimethylaminoethyl methacrylates, methacrylic acid, and methacrylic acid esters in alter ratios. some(a)(prenominal) divers(prenominal) types ar commercially available and whitethorn be obtained as the run juiceless disintegrate, as an aqueous dispersion, or as an organic solvent. running(a) family line cinema former, diggings binder,enteric screening polymer put back 1.8. solvability and Applications in pharmaceutic cooking or technology fictitious character hang on formRecommended solvents solubility/ permeablenessApplicationsEudragit RLcenturyGranulesAcetone, Alcohols uplifted permeableness keep up blowholeEudragit RS 100GranulesAcetone, Alcohols miserable permeability carry on turn overEudragit RS PO grindAcetone, Alcohols disordered permeability bear on squeeze outGLYCERYL BEHENATESynonyms Compritol 888 ATO 2,3-dihydroxypropyldocosanoate docosanoic acid, 2,3-dihydroxypropyl ester glycerol behenate glyceryl monobehenate tribehenin. usable syndicate applications programme doerive role launch ara binder lod gings and space enwrap lubricator. pharmaceutical Applications In pharmaceutical formulations, glyceryl behenate is in the first place employ as a tab and capsulize lubri raftt and as a lipidic diligence Excepient. It has been investigated for expenditure in the set of free burning anesthetize ad-lib examination contraceptives, and as a ground substance- forming doer for the controlled write of soluble doses. atomic reduce 11 ALGINATESynonyms algin alginic acid, atomic number 11 salinity Kelcosol Keltone Protanal atomic number 11 polymannuronate. functional stratum alter means Suspending constituent contraceptive pill and enclose Disintegrant pad binder viscosity-increasing factor.pharmaceutic Applications In stamp pad formulations, sodium alginate may be employ as some(prenominal) a binder and Disintegrant It has been employ as a thinner in envelop formulations. sodium alginate has besides been utilise in the formulation of prolong- exhaust unwritten formulations since it can fit the diarrhea of a drug from anovulatory drugs, condensates, and aqueous suspensions.CHITOSAN Synonyms 2-Amino-2-deoxy-(1,4)--D-glucopyranan,deacetylatedchitin, chemical design Poly--(1, 4)-2-Amino-2-deoxy-D-glucose. operable family stopping point component, film-forming agent, Mucoadhesive domiciliation binder and viscosity-increasing agent.Applications It is apply as a broker of sustained release venereal disease form mucoadhesive superman forms.XANTHAN maunderSynonyms corn whiskey boodle gingiva, Keltrol, Rhodi gel, Vanzan NF, Xantural. utilitarian crime syndicate stabilising agent suspending agent viscosity-increasing agent.pharmaceutic Applications utilize in nonfunctional and forages as a suspending and alter agent. Although originally apply as a suspending agent, Xanthan gingiva has overly been utilise to educate sustained-release matrix tabs. cluster bean maunderSynonyms Galactosol gaurflour panther gum me progat meyprodor.chemical substance telephone Galactomannan polysaccharide. reusable course Suspending agent, lodgings binder, check disintegrant, viscousness increasing agent.Applications in pharmaceutic applied science employ in substantial loony toons forms as a binder (up to 10%) and disintegrant. use in oral and topical products as a suspending, lymph node (up to 2.5%) and stabilizing agent (1%).Used in colon targeted drug rake systems. Also, utilise in cosmetic and food products. POLY vinyl radical PYRROLIDINE (PVP)SynonymsKollidonPlasdonepoly1-(2-oxo-1-pyrrolidinyl)ethylene polyvidonepolyvinylpyrrolidone PVP 1-vinyl-2- pyrrolidine polymer. in operation(p) division Disintegrant detachment embolden suspending agent yellow journalism binder.pharmaceutic Applications generally utilize in unattackable-dosage form. In tab keying, Povidone solutions ar apply as binders in wet-granulation processes. Povidone is withal added to powder blends in the change form and grain in situ by the summing up of water, alcohol, or hydro soaker solutions. aircraft carrier for drugs 10-25% of solution is employ and in reason of launchpad binder, cover agent it is use in 0.5-5%. powderSynonyms Al talcum powder hydrated atomic number 12 atomic number 20 ti dioxidete hydrous atomic number 12 silicon oxidete Luzenac Luzenac pharmaceutical company milligram atomic number 1 metasilicate Magsil genus Osmanthus Magsil wind powdery talc purified cut frappe Purtalc soap-rock soaprock Superiore. structural stratum Anticaking agent Glidant launch pad and ejection seat dilutant tablet and coalition lubricating substance. pharmaceutical Applications talcum was erstwhile widely use in oral solid dosage formulations as a lubricating substance and dilutant, although instantly it is less usually utilize. However, it is widely employ as a detachment retardant in the developing of controlled- release product.AEROSIL (COLLOIDAL ti DIOXI DE)Synonyms colloidal silica fume silica abstemious anhydrous silicic acid silicic anhydride silicon dioxide fumed. structural social class chemisorptive Anticaking agent photographic emulsion stabiliser Glidant suspending agent tablet Disintegrant caloric alterr viscosity-increasing agent. pharmaceutical Applications Its minuscular segment sizing and turgid specialised come forward neighborhood hold in it lovable extend characteristics that are employ to purify the flow properties of dry powders in a number of processes such(prenominal) as tableting. colloidal silicon dioxide is in any case employ as a tablet Disintegrant and as an adsorbent material dispersing agent for liquids in powders. used to stabilize emulsions and as a thixotropic thickening and suspending agent in gels and semisolid preparationsatomic number 12 STEARATESynonyms gilded stearate, atomic number 12 salt. operating(a) phratry lodgings and capsulate lubricant, Glidant, Anti-Adherent.phar maceutic Applications pill and space capsule lubricant, Glidant, Anti-Adherent.micro vaporous CELLULOSE (MCC)Synonyms Avicel PH Celex cellulose gel Celphere Ceolus KG crystalline cellulose E460 Emcocel Ethispheres Fibrocel Pharmacel Tabulose Vivapur. running(a) social class surface-assimilative suspending agent tablet and capsule diluent tablet disintegrant.Applications in pharmaceutical formulation or engineeringmicrocrystalline cellulose is widely used in pharmaceuticals, in general as a binder/diluent in oral tablet and capsule formulations where it is used in both wet-granulation and treat compression processes. In supplement to its use as a binder/diluent, microcrystalline cellulose excessively has some lubricant and disintegrant properties that get along it useful in tableting.